Endothelial progenitor cells in diabetes complications
نویسندگان
چکیده
منابع مشابه
Endothelial Progenitor Cells Dysfunction in Diabetes Mellitus
Diabetes mellitus (DM) is considered a leading cause of premature cardiovascular (CV) mortality and morbidity in general population and in individuals with known CV disease. Recent animal and clinical studies have shown that reduced number and weak function of endothelial progenitor cells (EPCs) may not only indicate to higher CV risk, but contribute to the impaired heart and vessels reparation...
متن کاملCirculating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus.
OBJECTIVES We sought to establish whether a reduction in endothelial progenitor cells (EPCs) has a putative role in peripheral vascular disease (PVD) of type 2 diabetic patients. BACKGROUND Peripheral vascular disease is a common and severe complication of diabetes mellitus. Impaired collateralization of diabetic vasculopathy has been extensively shown, but causes leading to its pathogenesis ...
متن کاملEndothelial Progenitor Cells in Diabetic Microvascular Complications: Friends or Foes?
Despite being featured as metabolic disorder, diabetic patients are largely affected by hyperglycemia-induced vascular abnormality. Accumulated evidence has confirmed the beneficial effect of endothelial progenitor cells (EPCs) in coronary heart disease. However, antivascular endothelial growth factor (anti-VEGF) treatment is the main therapy for diabetic retinopathy and nephropathy, indicating...
متن کاملSignificance of endothelial progenitor cells in subjects with diabetes.
D iabetes complications represent a huge burden for patients and health services. The fight against each single complication has led to significant improvements in diabetes care, especially for microvascular complications, yet macroangiopathy remains a major source of morbidity and mortality. A common approach for the prevention and treatment of diabetes complications relies on the understandin...
متن کاملMetformin improves circulating endothelial cells and endothelial progenitor cells in type 1 diabetes: MERIT study
BACKGROUND Type 1 diabetes is associated with increased cardiovascular disease (CVD). Decreased endothelial progenitor cells (EPCs) number plays a pivotal role in reduced endothelial repair and development of CVD. We aimed to determine if cardioprotective effect of metformin is mediated by increasing circulating endothelial progenitor cells (cEPCs), pro-angiogenic cells (PACs) and decreasing ci...
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ژورنال
عنوان ژورنال: Diabetes mellitus
سال: 2014
ISSN: 2072-0378,2072-0351
DOI: 10.14341/dm2015124-32